Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.—Mefloquine (250 mg every
7 days) is the current drug regimen recommended by the World Health Organization1 and the Centers for Disease Control and Prevention2 for prevention of malaria in East Africa. As indicated
in the article by Drs Lobel and Kozarsky,3
mefloquine treatment failure is well documented in Thailand and Cameroon.
In Africa, failure of mefloquine prophylaxis despite adequate drug concentration
has been documented in only 4 West African countries4
and in Somalia.5 We report a case of mefloquine
prophylaxis failure in a malaria naive resident of Kenya.
Kurtis JD, Koros JK, Duffy PE, Green MD. Malaria Prevention for Travelers. JAMA. 1998;279(13):990-991. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-13-jbk0401