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May 20, 1998

SV40-Contaminated Poliovirus Vaccine and Childhood Cancer Risk

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(19):1527-1528. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-19-jbk0520

To the Editor.—In examining the carcinogenic effects of exposure to simian virus 40 (SV40)–contaminated poliovirus vaccine, Strickler et al1 concluded that such exposure "was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas." The expectation that the available data provided reliable incidence rates for a comparative analysis using Poisson regression techniques deserves reconsideration.

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