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June 3, 1998

Role of Apoptosis in Health and Disease

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(21):1699-1700. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-21-jbk0603

To the Editor.—Apoptosis has received widespread attention over the past 5 years because it may play a role in a number of diseases ranging from cancer to stroke. Mr Hetts1 presents a detailed review of apoptosis in autoimmunity, cancer, and neurodegenerative disorders and concludes optimistically that knowledge of the intracellular apoptotic pathways may lead to a new armamentarium of therapeutic drugs for age-old diseases. What is lacking from this review is a critical appraisal of the evidence for and clinical relevance of apoptosis in disease.

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