Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.— In arguing against routine
antimicrobial treatment for AOM, Drs Culpepper and Froom1
cite randomized controlled trials by Halsted et al,2
van Buchem et al,3 and Appelman et al4 as showing neither short-term nor long-term differences
in outcome between antimicrobial-treated and placebo-treated subjects. That
interpretation overlooks or ignores key study results and limitations.
Paradise JL. Controversies: Treatment of Acute Otitis Media. JAMA. 1998;279(22):1783-1785. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-22-jac80008