Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.— The article by Dr O'Leary
and colleagues1 raises some important issues
of fairness in the interpretation of the data. Briefly, O'Leary et al tested
the performance of the PAPNET device on a cohort of 5478 Pap smears considered
to be negative. Although it is not clearly stated in their "Methods" section,
these smears apparently were screened twice before evaluation by PAPNET. This
is suggested by the subtitle of the article and by the discussion in the "Comment"
section. Despite these extraordinary precautions, PAPNET rescreening identified
11 Pap smears worthy of further review, resulting in at least 1 documented
SIL. Not surprisingly, the cost of this undertaking was very high.
Koss LG. Rescreening of Cervical Papanicolaou Smears Using PAPNET. JAMA. 1998;279(22):1785-1788. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-22-jac80008