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June 10, 1998

Rescreening of Cervical Papanicolaou Smears Using PAPNET

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor


Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(22):1785-1788. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-22-jac80008

To the Editor.— The article by Dr O'Leary and colleagues1 raises some important issues of fairness in the interpretation of the data. Briefly, O'Leary et al tested the performance of the PAPNET device on a cohort of 5478 Pap smears considered to be negative. Although it is not clearly stated in their "Methods" section, these smears apparently were screened twice before evaluation by PAPNET. This is suggested by the subtitle of the article and by the discussion in the "Comment" section. Despite these extraordinary precautions, PAPNET rescreening identified 11 Pap smears worthy of further review, resulting in at least 1 documented SIL. Not surprisingly, the cost of this undertaking was very high.

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