Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.— In their article, Dr
Misrahi and colleagues1 try to correlate
a CCR5 gene polymorphism with resistance to perinatal
human immunodeficiency virus (HIV) infection and progression of HIV disease.
The finding that Hardy-Weinberg equilibrium was obeyed for the cohort as a
whole, as well as the discovery that the CCR5Δ32
heterozygotes were distributed statistically evenly between the uninfected
and infected children, led them to conclude that such a genetic makeup did
not confer resistance to HIV infection. It would be interesting to know the CCR5 genotype of the mothers of the children in the study
population. Since it remains unclear exactly how heterozygosity for CCR5Δ32 changes the natural course of the disease,
one can imagine that the CCR5 genotype of mother
or child or both could play an important role in the risk of transmission.
Rascoff H. CCR5 Genotype and Mother-to-Child HIV Transmission. JAMA. 1998;279(24):1953. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-24-jac80011