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June 24, 1998

CCR5 Genotype and Mother-to-Child HIV Transmission—Reply

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(24):1953. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-24-jac80011

In Reply.—The CCR5 genotype analysis of the mother currently is being performed in the French cohort and probably in other studies throughout the world. We expect that univariate analysis will show a link between the CCR5Δ32 deletion and a lower transmission rate in children. However, it is now well established that plasma viral load is lower in heterozygous patients,1,2 and it also will be necessary to analyze these 2 parameters in a multivariate analysis since maternal viral load is a major determinant of the mother-to-child transmission risk.

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