Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
In Reply.—The CCR5 genotype analysis of the mother currently is being performed in the
French cohort and probably in other studies throughout the world. We expect
that univariate analysis will show a link between the CCR5Δ32 deletion and a lower transmission rate in children. However, it is
now well established that plasma viral load is lower in heterozygous patients,1,2 and it also will be necessary
to analyze these 2 parameters in a multivariate analysis since maternal viral
load is a major determinant of the mother-to-child transmission risk.
Blanche S. CCR5 Genotype and Mother-to-Child HIV Transmission—Reply. JAMA. 1998;279(24):1953. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-24-jac80011