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August 5, 1998

Relationship of Dietary Folate and Vitamin B6 With Coronary Heart Disease in Women

Author Affiliations

Margaret A.WinkerMDIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(5):417-419. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-5-jbk0805

To the Editor.—That there is a connection between folic acid, pyridoxine (vitamin B6), homocysteine, and heart disease in women seems to be well established on the basis of multiple studies.13 Of concern, however, is the reluctance by researchers to mention the established association between use of oral contraceptives and deficiency of folate, B vitamins, and other nutrients.

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