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September 9, 1998

Patients With Atrial Fibrillation at Low Risk of Stroke—Reply

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor


Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;280(10):882-883. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-10-jac80015

In Reply.—In response to Dr Cheung, the distinction between observed systolic BP higher than 160 mm Hg and a history of hypertension emerged from hypothesis-generating analyses of the derivation data set.1 Accepting the vagaries of this distinction, our criteria still effectively distinguished patients with AF, with stroke rates of nearly 10% per year for those with elevated systolic BP vs about 3.5% per year for those with a history of (mainly diastolic) hypertension—a clinically important difference.2 Any secondary analysis of ethnicity would, unfortunately, be limited because of the small numbers of heterogeneous minority participants. Compliance with aspirin was high in this study, and the clinical conditions leading to interruption of medication confound separate analysis of event rates in those not participating in therapy.

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