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November 11, 1998

Effect of Garlic on Serum Lipids

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(18):1568. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111

To the Editor.— The negative results from the clinical trial by Dr Berthold and colleagues1 investigating the cholesterol-lowering effect of a garlic oil product is a good example of a well-designed study that used a poor product and made an exaggerated conclusion. The authors concluded, "Garlic therapy for treatment of hypercholesterolemia cannot be recommended on the basis of this study." However, all that the authors are justified in concluding is that therapy with a steam-distilled garlic oil bound to beta cyclodextrin at a dose of 10 mg cannot be recommended.

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