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Books, Journals, New Media
November 11, 1998


Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(18):1568. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-18-jbk1111

In Reply.— We agree with Dr Lawson that garlic oil is not the same as garlic and that there are differences between various garlic preparations. Lawson criticizes our study for our choice of a steam-distilled garlic oil bound to a beta cyclodextrin matrix, suggesting that use of a water-soluble preparation would have shown lipid-lowering effects. We believe there is little evidence that powder preparations have lipid-lowering effects, even if Lawson attributes to them a significant efficacy on the basis of 17 of 20 studies cited in his recent review.1 Almost all of these studies were not as rigorously designed as 2 studies that used the popular allicin-standardized powder preparation (Kwai) and that showed no effect on blood lipids.2,3 We believe the negative result of our study is hardly attributable to the use of an oily preparation.

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