Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.—In the study by Dr Tang and colleagues,1 Hispanic subjects in a New York City community were at increased risk for developing Alzheimer disease (AD) compared with white non-Hispanic subjects. This elevated risk could not be attributed to the apolipoprotein E (APOE) genotype, since the relative risk of AD associated with the presence of an APOE-∊4 allele was 2.5 for whites vs 1.1 for Hispanics.
Barker W, Harwood D, Duara R, Mullan M, Fallin D, St. George Hyslop P, Rogaeva E, Song Y. The APOE-∊4 Allele and Alzheimer Disease Among African Americans, Hispanics, and Whites. JAMA. 1998;280(19):1661-1663. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-19-jbk1118