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November 25, 1998

Adverse Drug Reactions in Hospitalized Patients

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(20):1741. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-20-jac80013

To the Editor.—The practice of medicine has changed markedly since 1960. Continuous monitoring of vital signs, serum drug concentrations, and most drug-drug interactions either were not invented or were not recognized in the 1960s. Likewise, the important oversight role of the hospital pharmacist did not exist in the earlier studies included in the meta-analysis by Dr Lazarou and colleagues.1 Fully 14 of the 18 studies were performed prior to 1981, and I question the appropriateness of including these 14 studies in the meta-analysis.

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