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December 2, 1998

Rheumatic Fever

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;280(21):1830. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-21-jbk1202

To the Editor.—Stromal-derived factor (SDF-1) is the natural ligand for CXCR4, a coreceptor with CD4 for T-lymphocyte cell line–tropic human immunodeficiency virus 1 (HIV-1). Recently, a common variant, SDF1-3‘A, was identified in SDF-1, and an SDF1-3‘A/3‘A homozygous state was shown to delay the onset of acquired immunodeficiency syndrome (AIDS) in an association study involving 2857 patients.1 The recessive protection of the SDF-1-3‘A allele was pronounced to be twice as effective as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants.13

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