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December 16, 1998

Cost-effectiveness Analyses of Statistically Ineffective Treatments

Author Affiliations

Margaret A.WinkerMDIndividualAuthorPhil B.FontanarosaMD, Senior EditorsIndividualAuthor

JAMA. 1998;280(23):1992-1993. doi:10-1001/pubs.JAMA-ISSN-0098-7484-280-23-jbk1216

To the Editor.—Although the publication of guidelines1 has provided an important contribution to standardizing cost-effectiveness (CE) research, some methodological points still need clarification. In comparing treatment A (innovative treatment) with treatment B (reference treatment), a CE analysis is appropriate when A is more effective, ie, when the difference in clinical effectiveness between A and B is significant.

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