Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.—Dr Mercer et al1 demonstrated decreased infant infection and prolonged
pregnancy if antimicrobial treatment is given after preterm premature rupture
of the membranes (PPROM). As the authors indicate, intrauterine infection
is thought to cause many cases of PPROM. However, their study did not separate
PPROM due to ascending infection from PPROM due to other causes.
Cooperstock M. Premature Rupture of Membranes, Antibiotics, and Amnionitis. JAMA. 1998;279(1):22. doi:10.1001/jama.279.1.17