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January 7, 1998

Premature Rupture of Membranes, Antibiotics, and Amnionitis

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(1):22. doi:10.1001/jama.279.1.17

To the Editor.—Dr Mercer et al1 demonstrated decreased infant infection and prolonged pregnancy if antimicrobial treatment is given after preterm premature rupture of the membranes (PPROM). As the authors indicate, intrauterine infection is thought to cause many cases of PPROM. However, their study did not separate PPROM due to ascending infection from PPROM due to other causes.