Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.—Drs Leplége and
Hunt1 provide an incomplete view of the
current state of the science of HRQL measurement. We disagree with their pessimism
about the value of aggregated and normative outcome measures. Health outcomes
researchers must specify the conceptual model underlying an instrument; the
patients' perspective is critical in the development of HRQL measures. We
agree that patients are the main source for information about the content
and importance of domains to ensure that a quality-of-life measure adequately
reflects the impact of disease on functioning in everyday life and well-being.
Most current instruments start with eliciting concerns from patients (by qualitative
methods or focus groups) to determine the relevant domains.
Frank L, Kleinman L, Leidy NK, Legro M, Shikiar R, Revicki D. Defining and Measuring Quality of Life in Medicine. JAMA. 1998;279(6):429-431. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-6-jac81007