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Letters
February 11, 1998

Potential Chromosome 12 Locus for Late-Onset Familial Alzheimer Disease

Author Affiliations
 

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(6):433. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-6-jac81007

To the Editor.—In the article by Dr Pericak-Vance and colleagues,1 data obtained from a genomic screen in families with late-onset Alzheimer disease (AD) suggest the existence of a potential genetic risk factor on chromosome 12. Parametric and nonparametric linkage analyses demonstrated the strongest association for D12S373, D12S1057,D12S1042, and D12S390 in families that had at least 1 affected individual whose apolipoprotein E (APOE) genotype did not contain the ∊4 allele (APOE ∊4), suggesting that this region may harbor a new late-onset AD susceptibility gene with little or no dependence on APOE ∊4.

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