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February 18, 1998

Vitamin E Supplementation and Immune Response in Elderly Patients—Reply

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor


Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

JAMA. 1998;279(7):505-506. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-7-jbk0218

In Reply.— We appreciate the point raised by Dr Melhus regarding the influence of smoking on vitamin E requirements. However, this factor is not a confounder in our study because smoking was an exclusion criterion for the study subjects. Unfortunately, we neglected to mention this in the article.

Dr Herbert's suggestion that the financial contribution to our study by Hoffmann-LaRoche, Inc, biased its design and interpretation and caused us to omit the occurrence of adverse effects is made without evidence or merit. As our full disclosure to JAMA noted, none of the authors has any financial interest in Hoffmann-LaRoche or vitamin E supplements. As indicated in our article, major support for this study was from the US Department of Agriculture, along with a grant from Hoffman-LaRoche, Inc.

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