Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor
To the Editor.— I disagree with the conclusions
of the article by Dr Grönberg and colleagues1
on the characteristics of prostate cancer in families potentially linked or
potentially unlinked to the hereditary prostate cancer 1 (HPC1) gene.
First, on comparing the tumor stage in families potentially linked and
those not shown to be linked, the authors state there is higher-stage disease
with HPC1 linkage. This statement is based on a comparison
with a reference population from the National Cancer Database but not with
the unlinked families. When the linked and unlinked families are compared,
there is no difference (P=.16, Fisher exact test).
Laniado ME. Prostate Cancer Potentially Linked to the HPC1 Gene. JAMA. 1998;279(7):507-508. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-7-jbk0218