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February 18, 1998

Prostate Cancer Potentially Linked to the HPC1 Gene

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(7):507-508. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-7-jbk0218

To the Editor.— The discovery of the HPC1 locus by linkage studies was a major advance that allows the clinical characteristics of this form of hereditary prostate cancer to be described. It is noteworthy that the study design used by Dr Grönberg and colleagues1 included only family members with already diagnosed, clinically apparent prostate cancer. This design was chosen to avoid the detection of "phenocopies" (ie, patients with sporadic prostate cancer in a family with hereditary prostate cancer) that could affect the linkage analysis. The authors found that prostate cancer was diagnosed in these selected family members at a more advanced stage and grade and at an earlier age than in patients from families that did not link to HPC1.

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