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February 25, 1998

Effects of Age and Ethnicity on the Link Between APOE ∊4 and Alzheimer Disease

Author Affiliations

Margaret A.WinkerMD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Senior EditorIndividualAuthor

JAMA. 1998;279(8):580-582. doi:10-1001/pubs.JAMA-ISSN-0098-7484-279-8-jbk0225

To the Editor.—The APOE and Alzheimer Disease Meta Analysis Consortium has produced a valuable data set.1 Unfortunately, a comparison of Table 3 with Figure 4 suggests inconsistencies in their estimates. The odds ratio (OR) for apolipoprotein E (APOE) ∊3/∊4 for Japanese in Table 3 (5.6) is above the curve shown for Japanese in Figure 4. However, the clinic-based estimate for Caucasians (3.2) looks like the average of the points in Figure 4. Table 3 suggests the OR for APOE ∊3/∊4 is 75% higher among Japanese than among Caucasians. Figure 4 shows the difference is never more than 35% at any age. The differences between the methods used to derive these estimates might contribute to this.

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