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March 21, 2012

Urinary Sodium Excretion and Cardiovascular Events

Author Affiliations

Author Affiliation: Division of Nephrology and Hypertension, Weill Cornell Medical Center, New York, New York (sjmann@med.cornell.edu).

JAMA. 2012;307(11):1138-1139. doi:10.1001/jama.2012.326

To the Editor: Dr O’Donnell and colleagues, in their study on urinary sodium excretion and risk of cardiovascular events,1 reached the counterintuitive conclusion that sodium restriction increased the risk of cardiovascular events, which runs counter to the consistent evidence that, in individuals with hypertension, decreased sodium intake reduces blood pressure and improves the effectiveness of treatment with antihypertensive agents.24

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