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Book and Media Reviews
March 28, 2012

Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management

Author Affiliations

Author Affiliations: Departments of Internal Medicine and Hematology/Oncology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System (

JAMA. 2012;307(12):1319. doi:10.1001/jama.2012.348

Few textbooks are devoted to a single molecule. Yet hemoglobin is a spectacular molecule, without which life would not be possible. The history of hemoglobin dates to 1840, when Friedrich Hünefeld and others discovered that hemoglobin carries oxygen. Approximately 100 years later, Max Perutz discovered the molecular structure of hemoglobin by x-ray crystallography and was awarded the Nobel Prize for this work. The entire genomic structure of hemoglobin is now known, allowing for vast new amounts of information about its role in health and disease.

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