[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.204.247.205. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
November 16, 1929

INTRAVENOUS MEDICATIONPHYSIOLOGIC PRINCIPLES AND THERAPEUTIC APPLICATIONS

Author Affiliations

ROCHESTER, MINN.
From the Division of Medicine, the Mayo Clinic.

JAMA. 1929;93(20):1517-1522. doi:10.1001/jama.1929.02710200001001
Abstract

The importance of Harvey's demonstration of the circulation of the blood was early recognized by Robert Boyle and by Christopher Wren.1 They realized the possibility of intravenous medication and injected drugs intravenously into experimental animals. Their discussions regarding this subject evidently had a stimulating influence on other scientists and physicians of that day, for in the year 1665 Richard Lower2 performed the first direct transfusion of blood from one animal to another. Within two years, Denis of Paris carried out a similar transfusion from a sheep into a man without mishap. This therapeutic procedure was repeated on several occasions, but because of a fatal reaction the French civil authorities banned the further practice of transfusion in man. Experiences with infusion medication in different diseases gradually grew in number, but during the entire eighteenth century the attention of the medical profession was focused on bloodletting to the neglect of

First Page Preview View Large
First page PDF preview
First page PDF preview
×