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October 17, 1931

Studies of Protection Against Tuberculosis: Results with B. C. G. Vaccine in Monkeys.

JAMA. 1931;97(16):1174. doi:10.1001/jama.1931.02730160056042

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The great reputation of Dr. Griffith, whose pioneer experiments did much to develop our understanding of the relations of human and bovine tuberculosis, gives this pamphlet especial importance. The British Medical Research Council has taken the stand that the administration of B C G to children is unjustifiable until indisputable confirmation of Calmette's work has been obtained. The report here noted deals with experiments which Dr. Griffith made at the request of the council's committee on the bacteriology of tuberculosis. The experiments were confined to monkeys and to a considerable extent repeated the work of Wilbert, who directed the original B C G experiments of the Pasteur Institute on anthropoid apes in French Guinea. Griffith's experiments on monkeys, however, failed to confirm Wilbert, who reported a strong immunizing action of B C G. Griffith has found that B C G is indeed of low virulence for monkeys and is absorbed

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