Fogelson1 found that he could prepare from the gastric mucosa a neutral mucin which had a high combining power for free acid. Such a preparation has the requirements of an ideal antacid in that it does not markedly excite gastric secretion, is soothing or protective, and does not alter the body chemistry or disturb the gastro-intestinal tract. On feeding adequate quantities of this product to patients presenting peptic ulcer, Fogelson has obtained excellent preliminary results.
It occurred to us that it would be decidedly significant to ascertain whether the administration of this mucin would prevent the occurrence of ulcers in the dog, which are known to arise spontaneously following certain experimental procedures.
It has been shown that the exclusion of bile from the intestine may lead to the spontaneous development of single or multiple duodenal or gastric ulcers in the dog.
Kapsinow2 diverted the bile from the intestine
KIM MS, IVY AC. THE PREVENTION OF EXPERIMENTAL DUODENAL ULCER BY FEEDING NEUTRAL GASTRIC MUCIN. JAMA. 1931;97(21):1511-1513. doi:10.1001/jama.1931.02730210009003