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November 21, 1931

Experiments on Vitamin A Deficiency in Rats and the Quantitative Determination of Vitamin A.

JAMA. 1931;97(21):1560. doi:10.1001/jama.1931.02730210058035

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The busy clinician who expects to find in this monograph information dealing with the sources of vitamin A and their relative potencies will be disappointed. However, there is presented an excellent discussion of the pathology of vitamin A deficiency in the rat, the animal most commonly employed for such studies. The monograph deals with the finer details of the biologic technic for measuring this dietary essential, though, curiously enough, specific directions for calculating the relative potencies of substances tested are lacking. The many factors that have a bearing on the biologic method of assay of vitamin A are discussed and the extreme care required in carrying out the details of the assay as well as the interpretation of results is emphasized. While most of the points stressed in the book are commonly included in the practice of vitamin assay in this country, in several instances the experiences of Dr. Gudjónsson

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