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December 12, 1931


Author Affiliations


From the medical service of the Jewish Hospital.

JAMA. 1931;97(24):1757-1761. doi:10.1001/jama.1931.02730240007002

Although it has been nine years since Werner Schultz first described the new symptom complex which he termed agranulocytosis, and although several hundred cases have been reported in more or less detail, there is as yet no generally accepted definition by means of which the concept of the disease can be accurately circumscribed. Schultz's own definition of the disease is sharp enough: an acute febrile disease with angina, prostration and jaundice, a normal red blood picture, extreme leukopenia with nearly or quite complete absence of granulocytes, a normal number of blood platelets with absence of any tendency to hemorrhage, and an invariably fatal ending. Almost at once, however, cases were reported that lacked one or more of these cardinal symptoms. Jaundice was found more frequently absent than present; a considerable degree of secondary anemia is not rare in otherwise quite typical cases; instead of angina one may find ulcerative processes

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