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Article
December 12, 1931

BLOOD DISTURBANCES AND THROMBOGENESIS FROM CLINICAL INTRAVENOUS INJECTIONS OF DEXTROSE SOLUTIONS

JAMA. 1931;97(24):1800-1801. doi:10.1001/jama.1931.02730240050013
Abstract

In intravenous medication, more attention is often devoted to the details of technic of the injection than to the changes that may occur in the blood and in important physiologic functions following such administration. Even the apparent benefits of such injections are sometimes attributed to some trivial modification of a technic or to some minor or inconsequential modification of a solution. More important than such technical accessories in the choice of intravenous medication is the fundamental fact that agents, drugs or solutions so injected act as foreign agents in the blood stream. The presence of foreign bodies in the normal circulation, the direct effects on the blood and the indirect or reflex effects on various functions are obviously significant. The fact that the disturbances might be greater and more serious in pathologic conditions, in which intravenous solutions may be indicated, has scarcely received the consideration it deserves. Hence the results

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