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In the first part of the book the author discusses the normal and the pathologic physiology of the thyroid gland in their relations to the chemical composition of the gland, its histology, general metabolism, and the special histology of various nutritional elements. The geographic distribution of goiters throughout the world and their relation to lack of iodine in water and in agricultural products are studied. Original ideas as well as a criticism of former conceptions of hyperthyroidism are presented. The second part of the book is devoted to clinical considerations, and the author presents a physiopathologic classification of thyroid disorders, in which the presence or absence of hyperthyroidism is considered the essential point of differentiation and the determination of the basal metabolic rate is emphasized as being the most important piece of evidence in the differentiation of hypothyroid, normal and hyperthyroid states as well as in the estimation of the
Physiopathologie de la thyroïde: Diagnostic et traitement des goitres.. JAMA. 1931;97(24):1824. doi:10.1001/jama.1931.02730240074035