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A study of this case was undertaken because of the marked allergic manifestations to certain insulin products and because of the therapeutic problem which it presents.
C. G., a man, aged 38, gave a history of bilateral pleurisy at the age of 16, which was diagnosed as tuberculosis and treated with rest for a period of about two years. He had had influenza while in the army in 1918, with a recurrence of the old chest condition, and pneumonia in 1922. For many years he had experienced attacks manifested by a rash over the body, with swelling of the hands and lips, and itching of the skin, without known cause. The attacks lasted from one to four hours and disappeared spontaneously. His mother had had diabetes mellitus and died at the age of 72. His father died of emphysema. One brother died of asthma.
The start of the present illness
Grishaw WH. ALLERGIC MANIFESTATION TO INSULIN. JAMA. 1931;97(25):1885. doi:10.1001/jama.1931.27310250001014