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To the Editor:—
Recently, I ran across a bit of information which I think is valuable enough to be called to the attention of readers of The Journal. This was that the administration of immune globulin to close contactees of a patient with viral hepatitis may give a false 4+ positive cephalin flocculation test for from 3 to 6 weeks after injection. This is particularly important, because any minor illness in patients so inoculated could be confused with anicteric hepatitis. The difference is noted when other parameters of liver function are invoked and all are found to be normal.I recently had such a problem arise when 3 of a group of patients intimately exposed to viral hepatitis came down with flu-like symptoms several weeks later. Fortunately, in each case we were able to exclude the liver disease.
Kadish AH. Viral Hepatitis. JAMA. 1962;180(1):88. doi:10.1001/jama.1962.03050140090029