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December 19, 1931


Author Affiliations

Uppsala, Sweden

JAMA. 1931;97(25):1911. doi:10.1001/jama.1931.02730250069035

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To the Editor:  —Because of your interesting editorial on the distribution of bromides in the body (The Journal, October 17, p. 1152), I should like to call attention to an illustrative but apparently little known piece of work on this question. The work was published by Erik Wilén in the Uppsala läkareförenings förhandlingar31:373, 1926, and contains carefully performed bromide (Br-) and chloride (Cl-) analyses on different tissues from a man who died after having taken during three days a quantity of about 100 Gm. of sodium bromide. The death ensued about a week after the beginning of administration of the sodium bromide. Wilén calculates that about 50 per cent of the sodium bromide ingested remained in the body at the death. Like Toxopéus, he found the concentration of bromide (Br-) in the brain as a whole less than in several other tissues; e. g., blood, lungs, heart, spleen.

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