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January 9, 1932


Author Affiliations


From the Department of Medicine, Northwestern University Medical School, and the Medical Service of St. Luke's Hospital.

JAMA. 1932;98(2):99-104. doi:10.1001/jama.1932.02730280007003

Anginal pain as a result of the administration of digitalis has received relatively little attention in the literature. Occasional reference is made to the likelihood of this phenomenon, but more often the possibility is totally disregarded. In some instances it is stated that digitalis is capable of benefiting such pain. Fothergill,1 in his Hastings Prize Essay of the British Medical Society in 1870, argues that digitalis will improve the coronary flow. His conclusions are based on theoretical considerations and he cites but two cases in which angina pectoris improved while under digitalis therapy. Lauder Brunton's2 essay on digitalis at about the same time, does not touch on this question at all. Eggleston3 is convinced that any idea of coronary constriction in man is "misleading and erroneous" and cites the animal experiments of Meyer4 and of Sakai and Saneyoshi,5 the lack of satisfactory evidence in man,

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