At present, various chemical agents are being applied in order to destroy Trichomonas vaginalis. However, chemotherapy is frequently unsatisfactory for the following reasons: 1. In order to be effective, many chemicals must be used in concentrations that may be harmful to the vaginal mucosa, especially during prolonged treatment. 2. There is always a possibility that in the course of treatment a strain of the parasite may develop that is resistant to the chemotherapeutic agent. 3. Most of the chemotherapeutic methods are relatively complicated and cannot be applied by the patient at her home.
Taking into consideration the fact that protozoa in general are sensitive to variations in osmotic pressure of the surrounding medium, it occurred to us that the vaginal protozoon may also be affected by such variations. We therefore decided to study the action of hypertonic salt solutions on Trichomonas vaginalis.
The fact that Trichomonas vaginalis is an extra-cellular
ROSENTHAL L, SCHWARTZ LS, KALDOR J. TREATMENT OF TRICHOMONAS VAGINITIS WITH CONCENTRATED SALT SOLUTION. JAMA. 1935;105(2):105-106. doi:10.1001/jama.1935.02760280017005