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July 13, 1935


JAMA. 1935;105(2):108. doi:10.1001/jama.1935.02760280020007

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Dinitrophenol has been demonstrated to be a marked metabolic stimulant and as such has been recommended as an aid in the treatment of obesity. Extensive animal experimentation and a carefully controlled series of clinical cases convinced Dr. M. L. Tainter and his co-workers that dinitrophenol in proper dosage and properly controlled produced no deleterious effect on the human organism.

A few cases have appeared in the literature in which death occurred after the ingestion of dinitrophenol, but in these cases there had been excessive dosage or the drug had been continued after the appearance of some complicating condition. At the present time, dinitrophenol is quite generally accepted as an adjunct in the treatment of obesity, although among the more conservative it is used cautiously and with a certain degree of fear.

I myself have used it in several cases and with satisfactory results. However, in the last two weeks I

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