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Article
July 27, 1935

EVALUATION OF THE CONSTITUTIONAL EFFECTS OF LARGE DOSES OF ESTROGENIC PRINCIPLE

JAMA. 1935;105(4):257-263. doi:10.1001/jama.1935.02760300017005
Abstract

The present study was undertaken in an attempt to answer some of the questions propounded by the Council on Pharmacy and Chemistry of the American Medical Association in a recent report on the estrogenic substance theelin.1 Without dwelling at length on the merits or demerits of the substance as a therapeutic agent, the report of the Council pertinently states: "Evidence of deleterious effect from the clinical administration of estrogenic substance is not conclusive, but the possibility deserves serious consideration, particularly if the large doses more recently employed clinically should come into common usage." This study attempts to delineate the constitutional effects of huge doses of one of the estrogenic substances on the human female, as reflected in the ordinary laboratory and clinical studies at our disposal. This work is correlated with histologic studies of the vital organs of animals subjected to injections of enormous doses of the substance over

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