July 27, 1935


JAMA. 1935;105(4):285. doi:10.1001/jama.1935.02760300045012

For a quarter of a century the cholines have commanded the attention of research workers in medical science. The choline compounds, widely dispersed in nature, have been obtained from many vegetables and organic extracts as well as from certain drugs (especially ergot). The cholines may be considered to be quarternary ammonium bases; they produce two sets of actions: a "muscarine" effect and a "nicotine" effect.1

As early as 1914, Hunt and Taveau2 in an intensive study of cholines reported that one derivative, acetylcholine, was 100,000 times more depressant and only three times more toxic than choline itself. Another derivative in this group that has recently been used in therapeutic trials is acetyl beta methylcholine, described by Taveau2 in some of his earlier work. Hunt, at the time he was working in the Hygienic Laboratory of the United States Public Health Service, found that Taveau's preparation differed pharmacodynamically

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