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This article and the articles in the previous issues ofThe Journalare part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues. When completed, the series will be published in book form.—Ed.Every one requires insulin, and if a person cannot manufacture what he needs in his own pancreas he is fortunate if he can secure it by purchase or gift. No one, the normal person or the diabetic patient, knows the quantity required to maintain health and strength. Fortunate it is that nature regulates the supply with surprising accuracy, balancing its production with the carbohydrate consumed, whether this is for prompt utilization or for storage, and adjusting its output to the momentary demands of exercise or rest. This normal
JOSLIN EP, ROOT HF, WHITE P, MARBLE A. THERAPEUTIC APPLICATIONS OF INSULIN. JAMA. 1935;105(5):359-368. doi:10.1001/jama.1935.92760310005009