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August 3, 1935


JAMA. 1935;105(5):371-372. doi:10.1001/jama.1935.02760310045015

The utilization of sulphur for medicinal purposes was described as early as the time of Pliny,1 who attributed therapeutic value to this element in a wide variety of ailments. Medical interest in sulphur has been stimulated by the preparation of this material in forms2 whereby it may be introduced intramuscularly and intravenously. Much has been written concerning the wide therapeutic value of sulphur, but its use in widely different fields suggests that the theoretical basis of sulphur medication is largely empirical. As a result, the many beneficial results attending the administration of sulphur have been accompanied by a certain proportion of unfavorable prognoses. For example, the failure to observe aseptic precautions during intramuscular administration of preparations of sulphur in oil has frequently led to periostitis; in some instances the dangers of an oil embolism have been encountered. Notwithstanding these difficulties, injections of sulphur in oil have been widely

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