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August 24, 1935

A Review of Certain Aspects of a Recently Recognized Disease of the Blood (Agranulocytosis or Agranulocytic Angina)

JAMA. 1935;105(8):623. doi:10.1001/jama.1935.02760340069041

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This pamphlet consists of a brief review of the entire question of agranulocytosis, including history, nomenclature, clinical observations, etiology, prognosis, diagnosis and treatment. It was prepared by the author for official use of the ministry of health of Great Britain. No new material is presented, but an impartial and accurate summation of the disease is made with particular reference to some of the more controversial questions, such as etiology and methods of treatment. The author accepts the amidopyrine etiology of many cases of the disease. He deplores the confusion in terminology. Based on his review of the literature, he believes that pentnucleotide therapy is the best available. He states the total number of cases in Great Britain as twenty-two. An interesting record of one recovered patient is presented, showing the profound fall in granulocytes following the administration of a single dose of amidopyrine. This publication probably represents a general summation

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