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September 21, 1935


JAMA. 1935;105(12):958-959. doi:10.1001/jama.1935.92760380002010a

This case is of interest for the following reasons : 1. It is the first recorded instance of pentosuria occurring in twins. 2. One of the twins is a physician. 3. Reducing substances in the urine have been known to be present for seventeen years. 4. The cases were previously reported as juvenile diabetes in twins1 and as renal diabetes.2

History.  —L. W., a man, aged 28, a physician, and M. W., his twin sister, came under observation in 1918, at the age of 11 years, because the girl complained of irritation of the genitalia and thirst. Examination of the urine revealed sugar at this time. Because the two children always suffered simultaneously from the same diseases, the mother had the boy's urine examined, and sugar was found in it also. Shortly thereafter the children were hospitalized for further study. The urine showed a reducing substance, which was analyzed and thought

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