The value of ketonuria in the treatment of certain types of infections of the urinary tract has become widely recognized and utilized. Although the ketogenic diets recommended by Clark1 have proved their worth as a therapeutic agent, it has been constantly observed that a considerable proportion of patients placed on this regimen find it unpalatable, and many are completely unable to tolerate it. In a series of fifty cases treated by this method at the University Hospital, it was observed that practically every patient was upset by the diet at one time or another. The gastric upsets produced by its high fat content were so objectionable to some that they refused to continue on this regimen. Modifications of the diet were therefore made in an effort to remove this objectionable feature.
It has long been recognized as a fundamental principle of metabolism that the organism is not dependent on
NESBIT RM, McDONNELL CH. LOW CALORY, LOW FAT, KETOGENIC DIET FOR TREATMENT OF INFECTIONS OF URINARY TRACT. JAMA. 1935;105(15):1183–1184. doi:10.1001/jama.1935.02760410027009