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This monograph contains a series of five articles dealing with hypertension presented before the Medical Society of Berlin. Siebeck presents a somewhat theoretical discussion of the mechanisms of hypertension. Curtius emphasizes the need of considering in each individual the detailed family and personal history. Engel gives an excellent statistical summary of the relationship of the height of blood pressure to the prognosis of the patient with hypertension. This is based on 1,922 patients from the Heidelberg clinic and includes 884 who died. His careful analysis of statistical methods, with due regard to limitations, has led him to the conclusion that elevation of blood pressure foreshortens life, the prognosis being worse when the blood pressure is fixed at a constant high level. He recognizes that hypertension is not to be considered a systemic disease but rather as a symptom of a disturbance in function which has a definite prognostic significance. Even
Über Erkrankungen des arteriellen Systems. JAMA. 1935;105(19):1546. doi:10.1001/jama.1935.02760450066034