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In this lecture Leriche presents a summary of his views concerning angina pectoris and its surgical treatment based on experimental and clinical studies, which, with Fontaine, he has carried on for some ten years. For the details of these studies as well as for a comprehensive view of the whole subject of the surgical treatment of angina the reader must look elsewhere, for the author confines himself strictly to the topic; viz., his own conclusions based on his own work. Leriche accepts the coronary origin of angina yet considers spasm a prominent feature in some cases. Pain, he says, is a symptom and not the real disease. He discusses the physiology of the nervous mechanism involved in pain; also the importance of anastomosis as a compensatory factor. There are still many questions to be solved, such as the cause of thrombosis, which is the "greatest unknown factor in arteritis." The
Experimental and Clinical Researches on Angina Pectoris and Its Surgical Treatment. JAMA. 1935;105(21):1711. doi:10.1001/jama.1935.02760470065036