Following the publication in September 1934 by Silver and Reiner1 of studies on six cases of essential fructosuria, at Dr. Joslin's suggestion we set about to ascertain whether or not we had been, overlooking such cases in our patients with nondiabetic melituria. Earlier careful studies of the records and in certain instances special studies of the blood and urine of some 1,400 such patients had led to the reporting in 1932 of twenty-two cases of renal glycosuria possessing a very low renal threshold2 and three cases of chronic essential pentosuria.3 At that time, although Seliwanoff's test was carried out in each of the cases reported, no instance of fructosuria was disclosed.
Our procedure in the recent study has been as follows: On urine specimens found by the routine Benedict test to contain sugar, the test was repeated, but instead of the mixture of Benedict's solution and urine
MARBLE A, SMITH RM. ESSENTIAL FRUCTOSURIA. JAMA. 1936;106(1):24-26. doi:10.1001/jama.1936.02770010026007