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In May 1935 a mother consulted me about her son, aged 30 months, who had bilateral undescended testes. A complete physical examination showed no other abnormalities. The scrotum was empty, and the testes were not palpable.
Because of favorable results reported in the treatment of several cases of undescended testes with antuitrin-S, I proceeded to treat this child with it. Three injections of 1 cc. each were given three times a week every other day. After three weeks the scrotum began to turn pink and became swollen. In the left groin there appeared a small tumor about the size of a normal testicle. The child also complained of pain in the groin.
After about the eighth week of treatment the child began to have enuresis. He also developed a severe polydipsia. The child would wake at night, complaining of extreme thirst, gulping down a full glass of water
Koplin H. GLYCOSURIA CAUSED BY ADMINISTRATION OF ANTUITRIN-S FOR BILATERAL UNDESCENDED TESTES. JAMA. 1936;106(5):374. doi:10.1001/jama.1936.92770050002008a