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February 29, 1936

Current Comment

JAMA. 1936;106(9):710-711. doi:10.1001/jama.1936.02770090046017

EXPERIMENTAL AND CLINICAL SINUSITIS  Since 1930 Fenton and Larsell have carried on a series of investigations on sinus inflammations. Their studies have been made for the most part by observing the effects of surface applications to the membranes of the frontal sinus in cats. These membranes were first inflamed by inoculation with human strains of hemolytic streptococci. In a communication now appearing,1 these studies have been summarized. A number of preparations have been employed including histamine, azochloramide, aminoacetic acid, acetylcholine, amniotic fluid, isotonic chlorophyll, sodium alum and ten new compounds thought to have effects similar to those of ephedrine. Some of these substances have been tried also on patients. The investigators were forced to conclude from these studies that, owing to the defensive factors inherent in sinus epithelium and the connective tissue elements of its tunica propria, almost every preparation applied to the surface of such membranes becomes an

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