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May 16, 1936


JAMA. 1936;106(20):1753. doi:10.1001/jama.1936.02770200059027

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To the Editor—  In The Journal, January 25, page 279, Dr. J. M. Rogoff reported "Addison's Disease Following Adrenal Denervation in a Case of Diabetes Mellitus." While the diagnosis of Addison's disease was probably correct, it should be pointed out that necropsy was not permitted, and Dr. Rogoff's statement that "the surgical manipulations apparently resulted in occlusion of blood vessels and degeneration of the adrenal cortex" is pure speculation. Physiologists usually criticize post hoc propter hoc reasoning.The editorial (p. 294), apparently based on Rogoff's one unverified case, proceeds to attack irradiation of the pituitary and adrenal areas as a treatment of hypertension and suggests by inference that this is irradiation of the kidneys, which "is one effective way of producing hypertension." This statement is apparently predicated on the work of Page (Am. J. Physiol.112:166 [May] 1935). The writer appeared to be unfamiliar with Page's work or with

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